CENTB1, Polyclonal Antibody

Polyclonal CENTB1; Anti-CENTB1; ACAP1; Arf GAP with coiled coil; ANK repeat and PH domains 1; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1; centaurin; beta 1; Centaurin-beta-1; CENTB1; Cnt-b1; KIAA0050

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

CENTB1 antibody (Ser554) detects endogenous levels of CENTB1 only when phosphorylated at serine 554

CENTB1 antibody was purified by affinity chromatography

Supplied in liquid format, PBS buffer, pH 7.4, 150mM NaCl with added preservative 0.02% sodium azide  and 50% glycerol

1 mg/ml (lot specific)

Aliquot and store at -20 degree C. Avoid repeated freeze thaw cycles

Small volumes of anti-CENTB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal CENTB1 antibody (Ser554)

Cell Biology; Purified Polyclonal Antibodies

Immunohistochemistry (IHC), ELISA (EIA)

IHC: 1:50 - 1:100
ELISA: 1:1000

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Centaurin-beta1 (Phospho-Ser554) antibody.

81,536 Da

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

CENTB1; KIAA0050; Cnt-b1  [Similar Products]

ACAP1_HUMAN

CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, ARF

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; recycling endosome membrane

Molecular Function: zinc ion binding

Biological Process: protein transport; positive regulation of GTPase activity

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