A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3), ELI

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

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Small volumes of ADAMTS3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7220140 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAMTS3. The ELISA analytical biochemical technique of the MBS7220140 kit is based on ADAMTS3 antibody-ADAMTS3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cardiovascular

135,603 Da

ADAM metallopeptidase with thrombospondin type 1 motif, 3

A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS3; ADAMTS-3; PC II-NP; ADAM-TS 3; zinc metalloendopeptidase; procollagen II N-proteinase; procollagen II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3

A disintegrin and metalloproteinase with thrombospondin motifs 3

KIAA0366; ADAM-TS 3; ADAM-TS3; ADAMTS-3; PC II-NP  [Similar Products]

ATS3_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]

ADAMTS3: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Protein type: Secreted; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; fibril organization and biogenesis; protein processing; proteolysis; collagen biosynthetic process

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