Full Product Name
ABCB7 Antibody
Product Synonym Names
ABC transporter 7 protein; ABC7; anemia; sideroblastic; with spinocerebellar ataxia; ASAT; Atm1p; ATP-binding cassette 7; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette; sub-family B (MD
Product Gene Name
anti-ABCB7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75027
Specificity
ABCB7 Antibody detects endogenous levels of total ABCB7 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ABCB7.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ABCB7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCB7 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ABCB7 antibody
IHC: 1:50~1:100
ELISA: 1:5000
Immunohistochemistry (IHC) of anti-ABCB7 antibody
Immunohistochemistry analysis of paraffin-embedded human thymus gland, using ABCB7 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for ABCB7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001258625.1
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NCBI GenBank Nucleotide #
NM_001271696.2
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UniProt Primary Accession #
O75027
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UniProt Secondary Accession #
O75345; Q5VWY7; Q5VWY8; Q9BRE1; Q9UND1; Q9UP01; G3XAC4[Other Products]
UniProt Related Accession #
O75027[Other Products]
NCBI Official Full Name
ATP-binding cassette sub-family B member 7, mitochondrial isoform 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 7
NCBI Official Symbol
ABCB7 [Similar Products]
NCBI Official Synonym Symbols
ABC7; ASAT; Atm1p; EST140535
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NCBI Protein Information
ATP-binding cassette sub-family B member 7, mitochondrial
UniProt Protein Name
ATP-binding cassette sub-family B member 7, mitochondrial
UniProt Synonym Protein Names
ATP-binding cassette transporter 7; ABC transporter 7 protein
Protein Family
ABC transporter B family
UniProt Gene Name
ABCB7 [Similar Products]
UniProt Synonym Gene Names
ABC7; ABC transporter 7 protein [Similar Products]
NCBI Summary for ABCB7
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for ABCB7
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
Research Articles on ABCB7
1. data support a model in which cycloheximide -induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with ring sideroblasts
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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