Multidrug resistance protein 2, ELISA Kit

Multidrug resistance protein 2; ATP-binding cassette sub-family B member 4; P-glycoprotein 2; Abcb4; Mdr2; Pgy-2; Pgy2

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of Abcb4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2881176 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Multidrug resistance protein 2 (Abcb4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Abcb4. The ELISA analytical biochemical technique of the MBS2881176 kit is based on Abcb4 antibody-Abcb4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Abcb4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Abcb4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

140,377 Da

ATP-binding cassette, sub-family B (MDR/TAP), member 4

phosphatidylcholine translocator ABCB4

Phosphatidylcholine translocator ABCB4

MDR3_MOUSE

ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before *****hood. Two alternatively spliced human isoforms have been described.

Protein type: EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: apical plasma membrane; cytoplasm; Golgi membrane; integral to membrane; intercellular canaliculus; membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; phosphatidylcholine transmembrane transporter activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; bile acid secretion; lipid homeostasis; multidrug transport; phospholipid translocation; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cholesterol transport

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