Multidrug resistance protein 3, Polyclonal Antibody

ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; P-glycoprotein 2; P-glycoprotein 3; Abcb4; Mdr2; Pgy-2; Pgy2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Caprylic Acid Ammonium Sulfate Precipitation Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-Abcb4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

ELISA (EIA)

140,377 Da[Similar Products]

ATP-binding cassette, sub-family B (MDR/TAP), member 4

phosphatidylcholine translocator ABCB4

Phosphatidylcholine translocator ABCB4

MDR3_MOUSE

ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before *****hood. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter; Hydrolase; EC 3.6.3.44

Cellular Component: apical plasma membrane; cytoplasm; cytoplasmic vesicle; Golgi membrane; integral to membrane; intercellular canaliculus; membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; hydrolase activity; nucleotide binding; phosphatidylcholine transmembrane transporter activity; xenobiotic-transporting ATPase activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; bile acid secretion; lipid homeostasis; lipid transport; multidrug transport; phospholipid translocation; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cholesterol transport; transmembrane transport; transport

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