C1, Inhibitor

C-1 Esterase Inhibitor; Human Plasma Human C1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures.

Human Plasma

>95% by SDS-PAGE analysis

Frozen Liquid-0.02M Potassium Phosphate; 0.25M NaCl; pH 7.0

5.0 mg/ml (lot specific)

Store at -70 degree C.

Small volumes of SERPING1 inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Human C1 Inhibitor (also known as plasma protease C1 inhibitor, C1 esterase inhibitor, C1-inhibiting factor, C1-INH, and C1INA) is a single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, plasmin, Factors XIa and XIIa. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the C1EI is non-functional. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE.

Human C1 Inhibitor; Human Proteins

100000

serpin family G member 1

plasma protease C1 inhibitor

Plasma protease C1 inhibitor

C1IN; C1NH; C1 Inh; C1Inh  [Similar Products]

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.