Product Name
R-spondin-4 (Rspo4), Recombinant Protein
Full Product Name
Recombinant Mouse R-spondin-4 (Rspo4)
Product Gene Name
Rspo4 recombinant protein
[Similar Products]
Product Synonym Gene Name
Rspo4[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
20-228aa, Full Length of Mature Protein
Sequence
LYRRKKQAGT GLGGNCTGCV ICSEENGCST CQQRLFLFIR REGIRQYGKC VHDCPLGFFG IRGQEANRCK KCGATCESCF SQDFCIRCKR RFHLYKGKCL PSCPPGTLTH QSTRECQEEC EPSPWGSWSP CIHNGKTCGS GWGLETRVRE AGPAKQEETA SCRVLSESRK CPIKRLCPGE RNPRQKNRKD RRQRKDRKLE RRPHQRGSQ
3D Structure
ModBase 3D Structure for Q8BJ73
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Rspo4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Rspo4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035779.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001040689.1
[Other Products]
UniProt Primary Accession #
Q8BJ73
[Other Products]
UniProt Related Accession #
Q8BJ73[Other Products]
Molecular Weight
16,389 Da
NCBI Official Full Name
R-spondin-4
NCBI Official Synonym Full Names
R-spondin 4
NCBI Official Symbol
Rspo4 [Similar Products]
NCBI Official Synonym Symbols
A730099F22; A930029K19Rik
[Similar Products]
NCBI Protein Information
R-spondin-4
UniProt Protein Name
R-spondin-4
UniProt Synonym Protein Names
Cysteine-rich and single thrombospondin domain-containing protein 4; Cristin-4; mCristin-4; Roof plate-specific spondin-4
UniProt Gene Name
Rspo4 [Similar Products]
UniProt Synonym Gene Names
Cristin-4; mCristin-4 [Similar Products]
UniProt Comments for Rspo4
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
