Full Product Name
GNAQ Antibody, FITC conjugated
Product Synonym Names
Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein alpha-q; GNAQ; GAQ
Product Gene Name
anti-GNAQ antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P50148
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Guanine nucleotide-binding protein G(q) subunit alpha protein (1-359AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26791 / sc-393
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GNAQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNAQ antibody
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).
Applications Tested/Suitable for anti-GNAQ antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GNAQ. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002063.2
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NCBI GenBank Nucleotide #
NM_002072.4
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UniProt Primary Accession #
P50148
[Other Products]
UniProt Secondary Accession #
O15108; Q13462; Q6NT27; Q92471; Q9BZB9[Other Products]
UniProt Related Accession #
P50148[Other Products]
Molecular Weight
42,142 Da
NCBI Official Full Name
guanine nucleotide-binding protein G(q) subunit alpha
NCBI Official Synonym Full Names
G protein subunit alpha q
NCBI Official Symbol
GNAQ [Similar Products]
NCBI Official Synonym Symbols
GAQ; SWS; CMC1; G-ALPHA-q
[Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein G(q) subunit alpha
UniProt Protein Name
Guanine nucleotide-binding protein G(q) subunit alpha
UniProt Synonym Protein Names
Guanine nucleotide-binding protein alpha-q
UniProt Gene Name
GNAQ [Similar Products]
UniProt Synonym Gene Names
GAQ [Similar Products]
UniProt Entry Name
GNAQ_HUMAN
NCBI Summary for GNAQ
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
UniProt Comments for GNAQ
G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide .
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 9q21
Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane
Molecular Function: GTPase activator activity; GTPase activity; protein binding; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential
Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome
Research Articles on GNAQ
1. data suggest that the interaction between this novel region in Galphaq and the effector PKCzeta is a key event in Galphaq signaling.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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