Fibroblast Growth Factor Receptor Substrate 3, Polyclonal Antibody

Anti -Fibroblast Growth Factor Receptor Substrate 3 (FRS3, FGFR Substrate 3, FGFR-signaling adaptor SNT2, Suc1-associated Neurotrophic Factor Target 2, SNT-2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (41737914..41747630, complement). Location: 6p21.1

Polyclonal

IgG

Rabbit

Recognizes human FRS3/FRS2b. Species crossreactivity: mouse, rat.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-FRS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Fibroblast growth factor receptor substrate 3 (FRS3) is an adapter protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. FRS3 is also designated as FRS2beta and SNT2 (Suc1 associated neurotrophic factor target protein).

Antibodies; Abs to Transcription Factors

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 1:2000

54,462 Da[Similar Products]

fibroblast growth factor receptor substrate 3

fibroblast growth factor receptor substrate 3; FRS2-beta; FGFR substrate 3; OTTHUMP00000016383; FGFR-signaling adaptor SNT2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)

Fibroblast growth factor receptor substrate 3

FRS3_HUMAN

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq]

FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Molecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: fibroblast growth factor receptor signaling pathway; signal transduction

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.