Full Product Name
PDP1 Polyclonal Antibody
Product Synonym Names
Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial; PDP 1; EC 3.1.3.43; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1; PDP1; PDP; PPM2C
Product Gene Name
anti-PDP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9P0J1
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 180-260
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PDP1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PDP1 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for PDP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001155251.1
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NCBI GenBank Nucleotide #
NM_001161779.1
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UniProt Primary Accession #
Q9P0J1
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UniProt Secondary Accession #
Q5U5K1; B3KX71; J3KPU0[Other Products]
UniProt Related Accession #
Q9P0J1[Other Products]
NCBI Official Full Name
pyruvate dehyrogenase phosphatase catalytic subunit 1 isoform 2
NCBI Official Synonym Full Names
pyruvate dehyrogenase phosphatase catalytic subunit 1
NCBI Official Symbol
PDP1 [Similar Products]
NCBI Official Synonym Symbols
PDH; PDP; PDPC; PPM2A; PPM2C
[Similar Products]
NCBI Protein Information
pyruvate dehyrogenase phosphatase catalytic subunit 1
UniProt Protein Name
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
UniProt Synonym Protein Names
Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1
Protein Family
PWWP domain-containing protein
UniProt Gene Name
PDP1 [Similar Products]
UniProt Synonym Gene Names
PDP; PPM2C; PDP 1; PDPC 1 [Similar Products]
NCBI Summary for PDP1
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
UniProt Comments for PDP1
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Research Articles on PDP1
1. High PDH expression is associated with glucose intolerance.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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