Product Name
4-1BB/TNFRSF9/CD137, Recombinant Protein
Full Product Name
Recombinant Human 4-1BB/TNFRSF9/CD137 Protein
Product Synonym Names
4-1BB; CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA
Product Gene Name
4-1BB recombinant protein
[Similar Products]
Product Synonym Gene Name
TNFRSF9; CD137[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
LQDPCSNCPA GTFCDNNRNQ ICSPCPPNSF SSAGGQRTCD ICRQCKGVFR TRKECSSTSN AECDCTPGFH CLGAGCSMCE QDCKQGQELT KKGCKDCCFG TFNDQKRGIC RPWTNCSLDG KSVLVNGTKE RDVVCGPSPA DLSPGASSVT PPAPAREPGH SPQ
3D Structure
ModBase 3D Structure for Q07011
Purity/Purification
> 95% by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 muM filtered solution of PBS, pH 7.4.
Endotoxin
< 1 EU/mug of the protein by LAL method.
Tag
Fc tag at the C-terminus
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Protein Construction
High quality, high purity and low endotoxin recombinant Recombinant Human 4-1BB/TNFRSF9/CD137 Protein (RP00935), tested reactivity in Human and has been validated in SDS-PAGE.100% guaranteed.
Preparation and Storage
Store the lyophilized protein at-20 degree C to-80 degree C for long term.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.
Other Notes
Small volumes of 4-1BB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
4-1BB recombinant protein
Recombinant Human 4-1BB/TNFRSF9/CD137 Protein is produced by human cells expression system. The target protein is expressed with sequence (Leu24-Gln186) of human 4-1BB/TNFRSF9/CD137 (Accession #Q07011) fused with an Fc tag at the C-terminus.
SDS-Page of 4-1BB recombinant protein
Recombinant Mouse CD157/BST1/ADP-ribosyl cyclase 2/Cyclic ADP-ribose hydrolase 2 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
NCBI/Uniprot data below describe general gene information for 4-1BB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001552.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001561.5
[Other Products]
UniProt Primary Accession #
Q07011
[Other Products]
UniProt Related Accession #
Q07011[Other Products]
Molecular Weight
27,899 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 9
NCBI Official Synonym Full Names
TNF receptor superfamily member 9
NCBI Official Symbol
TNFRSF9 [Similar Products]
NCBI Official Synonym Symbols
ILA; 4-1BB; CD137; CDw137
[Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
UniProt Gene Name
TNFRSF9 [Similar Products]
UniProt Synonym Gene Names
CD137; ILA [Similar Products]
NCBI Summary for 4-1BB
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for 4-1BB
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Research Articles on 4-1BB
1. 3 SNPs (rs161827, rs161818, and rs161810) of the CD137 gene and their association with ischemic stroke were studied in a northern Chinese Han population. rs161827 was significantly different between patients with and without diabetes and the controls. rs161818 and rs161810 differed significantly between patients without diabetes and the controls. All 3 were statistically significant in the combination stroke group.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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