Full Product Name
TAF15 Polyclonal Antibody
Product Synonym Names
Npl3; RBP56; TAF2N; TAFII68
Product Gene Name
anti-TAF15 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92804
Purity/Purification
Antigen affinity purification
Concentration
1mg/ml (lot specific)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Immunogen
Recombinant protein of human TAF15
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109061
Preparation and Storage
Store at -20 degree C. Avoid freeze/ thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-TAF15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TAF15 antibody
Immunohistochemistry (IHC)
Application Notes for anti-TAF15 antibody
Immunohistochemistry: 1:50 - 1:100
Immunohistochemistry (IHC) of anti-TAF15 antibody
Immunohistochemistry of paraffin-embedded human gastric using TAF15 antibody at dilution of1:100 (x40 lens).
Immunohistochemistry (IHC) of anti-TAF15 antibody
Immunohistochemistry of paraffin-embedded human esophagus using TAF15 antibody at dilution of1:100 (x40 lens).
NCBI/Uniprot data below describe general gene information for TAF15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003478.1
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NCBI GenBank Nucleotide #
NM_003487.3
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UniProt Primary Accession #
Q92804
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UniProt Secondary Accession #
Q86X94; Q92751; B2R837[Other Products]
UniProt Related Accession #
Q92804[Other Products]
Molecular Weight
61,558 Da
NCBI Official Full Name
TATA-binding protein-associated factor 2N isoform 2
NCBI Official Synonym Full Names
TATA-box binding protein associated factor 15
NCBI Official Symbol
TAF15 [Similar Products]
NCBI Official Synonym Symbols
Npl3; RBP56; TAF2N; TAFII68
[Similar Products]
NCBI Protein Information
TATA-binding protein-associated factor 2N
UniProt Protein Name
TATA-binding protein-associated factor 2N
UniProt Synonym Protein Names
68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56
Protein Family
Transcription initiation factor
UniProt Gene Name
TAF15 [Similar Products]
UniProt Synonym Gene Names
RBP56; TAF2N; TAF(II)68; TAFII68 [Similar Products]
UniProt Entry Name
RBP56_HUMAN
NCBI Summary for TAF15
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for TAF15
TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Translation; RNA-binding
Chromosomal Location of Human Ortholog: 17q11.1-q11.2
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of transcription, DNA-dependent
Disease: Chondrosarcoma, Extraskeletal Myxoid
Research Articles on TAF15
1. our data suggest that TAF15 and TLS/FUS operate within similar but not identical hnRNP M-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type.
Precautions
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Disclaimer
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