Full Product Name
LOXL1 Antibody BIOTIN-Conjugated
Product Synonym Names
Lysyl oxidase like 1; LOL; Lysyl oxidase homolog 1; Lysyl oxidase like protein 1 antibody
Product Gene Name
anti-LOXL1 antibody
[Similar Products]
Matching Pairs
Antibody: LOXL1 (MBS542010)
Positive Control: LOXL1 (MBS542920)
Antibody/Peptide Pairs
LOXL1 peptide (MBS543939) is used for blocking the activity of LOXL1 antibody (MBS542010)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P97873
Form/Format
BIOTIN-Conjugated
Concentration
0.66 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 570-620 on rat LOXL1 protein.
Molecular Function
Copper ion binding, oxidereductase activity acting on the CH-NH2 group of donors and oxygen as accecptor
Subcellular Location
Secreted, Extracellular space
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-LOXL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LOXL1 antibody
BIOTIN-Conjugated Loxl1 protein Antibody
Active on elastin and collagen substrates.
Applications Tested/Suitable for anti-LOXL1 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), IMM, Western Blot (WB)
Application Notes for anti-LOXL1 antibody
Dot Blot: 1:20,000-1:50,000
ELISA: 1:20,000-1:50,000
Western Blot: 1:500-1:1,000
NCBI/Uniprot data below describe general gene information for LOXL1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH03973.1
[Other Products]
UniProt Primary Accession #
P97873
[Other Products]
UniProt Secondary Accession #
Q91ZY4; Q99KX3[Other Products]
UniProt Related Accession #
P97873[Other Products]
Molecular Weight
66,506 Da
NCBI Official Full Name
Loxl1 protein, partial
NCBI Official Synonym Full Names
lysyl oxidase-like 1
NCBI Official Symbol
Loxl1 [Similar Products]
NCBI Official Synonym Symbols
Loxl
[Similar Products]
NCBI Protein Information
lysyl oxidase homolog 1
UniProt Protein Name
Lysyl oxidase homolog 1
UniProt Synonym Protein Names
Lysyl oxidase 2; Lysyl oxidase-like protein 1
Protein Family
Lysyl oxidase
UniProt Gene Name
Loxl1 [Similar Products]
UniProt Synonym Gene Names
Lox2; Loxl [Similar Products]
UniProt Entry Name
LOXL1_MOUSE
UniProt Comments for LOXL1
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: EC 1.4.3.-; Secreted, signal peptide; Extracellular matrix; Oxidoreductase; Secreted
Cellular Component: acrosome; basement membrane; cytoplasm; extracellular matrix; extracellular region; proteinaceous extracellular matrix
Molecular Function: aspartate oxidase activity; copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding
Research Articles on LOXL1
1. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.
Precautions
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Disclaimer
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