Full Product Name
Loxl1 Antibody, HRP conjugated
Product Synonym Names
Lysyl oxidase homolog 1 (EC:1.4.3.-); Loxl1; Lox2; Loxl; Lysyl oxidase 2; Lysyl oxidase-like protein 1
Product Gene Name
anti-Loxl1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P97873
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant mouse Lysyl oxidase homolog 1 protein
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-Loxl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Loxl1 antibody
Active on elastin and collagen substrates.
Applications Tested/Suitable for anti-Loxl1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for Loxl1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034859.2
[Other Products]
NCBI GenBank Nucleotide #
NM_010729.3
[Other Products]
UniProt Primary Accession #
P97873
[Other Products]
UniProt Secondary Accession #
Q91ZY4; Q99KX3[Other Products]
UniProt Related Accession #
P97873[Other Products]
Molecular Weight
66,506 Da
NCBI Official Full Name
lysyl oxidase homolog 1
NCBI Official Synonym Full Names
lysyl oxidase-like 1
NCBI Official Symbol
Loxl1 [Similar Products]
NCBI Official Synonym Symbols
Loxl
[Similar Products]
NCBI Protein Information
lysyl oxidase homolog 1
UniProt Protein Name
Lysyl oxidase homolog 1
UniProt Synonym Protein Names
Lysyl oxidase 2; Lysyl oxidase-like protein 1
Protein Family
Lysyl oxidase
UniProt Gene Name
Loxl1 [Similar Products]
UniProt Synonym Gene Names
Lox2; Loxl [Similar Products]
UniProt Entry Name
LOXL1_MOUSE
UniProt Comments for Loxl1
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: Secreted, signal peptide; Extracellular matrix; Secreted; EC 1.4.3.-; Oxidoreductase
Cellular Component: acrosome; basement membrane; cytoplasm; extracellular matrix; extracellular region; proteinaceous extracellular matrix
Molecular Function: aspartate oxidase activity; copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding
Research Articles on Loxl1
1. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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