Full Product Name
TSC2 Polyclonal Antibody
Product Synonym Names
LAM; TSC4; PPP1R160
Product Gene Name
anti-TSC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Concentration
1.4mg/ml (lot specific)
Immunogen
Synthetic peptide of human TSC2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-893 / sc-13012 / sc-892
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-TSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSC2 antibody
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications Tested/Suitable for anti-TSC2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TSC2 antibody
ELISA: 1:1000-2000
IHC: 1:10-50
WB: 1:200-1000
Immunohistochemistry (IHC) of anti-TSC2 antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer using TSC2 Polyclonal Antibody at dilution of 1/20
Western Blot (WB) of anti-TSC2 antibody
Western Blot analysis of A172 cells using TSC2 Polyclonal Antibody at dilution of 1/200
NCBI/Uniprot data below describe general gene information for TSC2. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_012680.3
[Other Products]
UniProt Related Accession #
P49816[Other Products]
NCBI Official Full Name
tuberin
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
Tsc2 [Similar Products]
NCBI Official Synonym Symbols
Rc
[Similar Products]
NCBI Protein Information
tuberin
UniProt Protein Name
Tuberin
UniProt Synonym Protein Names
Tuberous sclerosis 2 protein homolog
UniProt Gene Name
Tsc2 [Similar Products]
UniProt Entry Name
TSC2_RAT
NCBI Summary for TSC2
acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]
UniProt Comments for TSC2
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Research Articles on TSC2
1. Therefore, we conclude that glycolysis is restrained in the livers of TSC2 heterozygous mutant rats, and these defects lead to abnormal production of acetoacetate.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
