Full Product Name
Ccna1, ID (Ccna1, Cyclin-A1)
Product Synonym Names
Anti -Ccna1, ID (Ccna1, Cyclin-A1)
Product Gene Name
anti-CCNA1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 13; NC_000013.10 (37005257..37017019). Location: 13q12.3-q13
3D Structure
ModBase 3D Structure for P78396
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
Mouse Ccna1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-188 amino acids from the Central region of mouse Ccna1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CCNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCNA1 antibody
Ccna1 may be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Product Categories/Family for anti-CCNA1 antibody
Antibodies; Abs to Cyclin
Applications Tested/Suitable for anti-CCNA1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CCNA1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for CCNA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104517.1
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NCBI GenBank Nucleotide #
NM_001111047.1
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UniProt Primary Accession #
P78396
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UniProt Secondary Accession #
Q5T3V0; Q5U0G2; Q8IY91; B7Z7E3[Other Products]
UniProt Related Accession #
P78396[Other Products]
Molecular Weight
52,358 Da[Similar Products]
NCBI Official Full Name
cyclin-A1 isoform c
NCBI Official Synonym Full Names
cyclin A1
NCBI Official Symbol
CCNA1 [Similar Products]
NCBI Protein Information
cyclin-A1
UniProt Protein Name
Cyclin-A1
UniProt Gene Name
CCNA1 [Similar Products]
UniProt Entry Name
CCNA1_HUMAN
NCBI Summary for CCNA1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CCNA1
CCNA1: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA); Nuclear receptor co-regulator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 13q12.3-q13
Cellular Component: nucleoplasm; microtubule cytoskeleton; cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; mitosis; male meiosis I; cell division; regulation of G2/M transition of mitotic cell cycle; spermatogenesis; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Research Articles on CCNA1
1. Nuclear FoxO3a promotes cell cycle progression by transcriptional upregulation of cyclin A1, promoting proliferation of human anaplastic thyroid carcinoma cells.
Precautions
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Disclaimer
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