GNAQ, Polyclonal Antibody

Anti-GNAQ Antibody IHC-plus; GNAQ; G-ALPHA-q; GAQ; Human GNAQ

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human GNAQ

Immunoaffinity Purified

0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal

1 mg/ml (lot specific)

Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.

Small volumes of anti-GNAQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (10 ug/ml), WB
Usage: Antibody reactive against recombinant protein, detects immunogen.

Anti-GNAQ antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

42,142 Da

guanine nucleotide binding protein (G protein), q polypeptide

guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein alpha-q

Guanine nucleotide-binding protein G(q) subunit alpha

GAQ  [Similar Products]

GNAQ_HUMAN

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]

G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide .

Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 9q21

Cellular Component: nuclear membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; protein binding; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activator activity

Biological Process: regulation of action potential; platelet activation; protein stabilization; maternal behavior; metabolic process; glutamate signaling pathway; heart development; pigmentation during development; G-protein signaling, adenylate cyclase activating pathway; post-embryonic development; regulation of melanocyte differentiation; phospholipase C activation; forebrain neuron development; negative regulation of protein kinase activity; embryonic digit morphogenesis; dopamine receptor, phospholipase C activating pathway; blood coagulation; skeletal development; positive regulation of GTPase activity; neuron remodeling

Disease: Sturge-weber Syndrome; Capillary Malformations, Congenital

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