GNAQ, Recombinant Protein

Guanine nucleotide-binding protein G (q) subunit alpha; CMC1; G-ALPHA-q; GAQ; SWS

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 90% by SDS-PAGE

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

0.5 mg/ml (determined by Bradford assay) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of GNAQ recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GNAQ is a guanine nucleotide-binding protein. GNAQ, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2. Recombinant human GNAQ protein, fused to His-tag at N-terminus, was expressed in E Coli.

Cardiovascular

SDS-PAGE

44.5kDa (382aa)

G protein subunit alpha q

guanine nucleotide-binding protein G(q) subunit alpha

Guanine nucleotide-binding protein G(q) subunit alpha

GAQ  [Similar Products]

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) ().

Mudhar,H.S, et al. (2013) Br J Ophthalmol 97 (7), 924-928; Chishiki,K., et al. (2013) Biochem. Biophys. Res. Commun. 435 (3), 414-419

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