Full Product Name
Human 4-1BB Affinity Purified Polyclonal
Product Synonym Names
RAA05020; polyclonal; 4-1BB
Product Gene Name
anti-4-1BB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (7975931..8003225, complement). Location: 1p36
3D Structure
ModBase 3D Structure for Q07011
Preparation and Storage
This antibody can be stored in working aliquots at 2C - 8C for one month without detectable loss of activity. The antibody is stable for at least 1 year from date of receipt at -20C.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-4-1BB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-4-1BB antibody
Antigen affinity polyclonals
Application Notes for anti-4-1BB antibody
Western Blot Concentration: 0.1-0.2 ug/ml
Western Blot Limit: 1 ng/lane
ELISA Concentration: 0.1-0.2 ug/ml
ELISA Limit: 5 pg/well
NCBI/Uniprot data below describe general gene information for 4-1BB. It may not necessarily be applicable to this product.
NCBI Accession #
AAA53133.1
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UniProt Primary Accession #
Q07011
[Other Products]
UniProt Related Accession #
Q07011; AAB34924[Other Products]
Molecular Weight
27,899 Da
NCBI Official Full Name
4-1BB
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol
TNFRSF9 [Similar Products]
NCBI Official Synonym Symbols
ILA; 4-1BB; CD137; CDw137
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NCBI Protein Information
tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA
UniProt Gene Name
TNFRSF9 [Similar Products]
UniProt Synonym Gene Names
CD137; ILA [Similar Products]
UniProt Entry Name
TNR9_HUMAN
NCBI Summary for 4-1BB
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for 4-1BB
TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane
Molecular Function: cytokine binding; receptor activity
Biological Process: negative regulation of cell proliferation; apoptosis
Research Articles on 4-1BB
1. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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