Neuroligin-4, ELISA Kit

Neuroligin-4; X-linked; Neuroligin X; HNLX; NLGN4X; KIAA1260; NLGN4; UNQ365/PRO701

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of NLGN4X elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9428563 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neuroligin-4 (NLGN4X) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NLGN4X. The ELISA analytical biochemical technique of the MBS9428563 kit is based on NLGN4X antibody-NLGN4X antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NLGN4X antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NLGN4X. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

94,047 Da

neuroligin 4, X-linked

neuroligin-4, X-linked

Neuroligin-4, X-linked

KIAA1260; NLGN4; Neuroligin X  [Similar Products]

This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

NLGN4X: Putative neuronal cell surface protein involved in cell- cell-interactions. Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.32-p22.31

Cellular Component: cell surface; dendrite; excitatory synapse; integral to plasma membrane; plasma membrane; synapse

Molecular Function: cell adhesion molecule binding; chloride ion binding; neurexin binding; protein binding; protein homodimerization activity; receptor activity

Biological Process: ***** behavior; cerebellum development; learning; neuron adhesion; organ growth; social behavior; synapse organization and biogenesis; synaptic vesicle endocytosis

Disease: Asperger Syndrome, X-linked, Susceptibility To, 2; Autism, Susceptibility To, X-linked 2

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