collagen, type V, alpha 1, ELISA Kit

Mouse Collagen alpha-1 (V) chain (COL5A1) ELISA kit; RP11-263F14.1; alpha 1 type V collagen; collagen; type V; alpha 1

For Research Use Only. Not for use in diagnostic procedures.

This assay has high sensitivity and excellent specificity for detection of Mouse COL5A1. No significant cross-reactivity or interference between Mouse COL5A1 and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of COL5A1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS932248 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the collagen, type V, alpha 1 (COL5A1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL5A1. The ELISA analytical biochemical technique of the MBS932248 kit is based on COL5A1 antibody-COL5A1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL5A1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL5A1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

183,677 Da

collagen, type V, alpha 1

collagen alpha-1(V) chain; collagen alpha-1(V) chain; alpha1(V) collagen; pro-alpha1(V) collagen; procollagen type V alpha 1; procollagen, type V, alpha 1

Collagen alpha-1(V) chain

CO5A1_MOUSE

COL5A1: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.

Protein type: Secreted; Extracellular matrix; Cell adhesion; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; collagen type V; extracellular region; basement membrane

Molecular Function: heparin binding; protein binding; proteoglycan binding; extracellular matrix structural constituent; platelet-derived growth factor binding

Biological Process: heart morphogenesis; skin development; blood vessel development; cell migration; integrin biosynthetic process; collagen fibril organization; regulation of cellular component organization and biogenesis; fibril organization and biogenesis; cell adhesion; collagen biosynthetic process; eye morphogenesis; wound healing, spreading of epidermal cells

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