Product Name
Caspase Nc (Nc), Recombinant Protein
Full Product Name
Recombinant Drosophila melanogaster Caspase Nc (Nc)
Product Gene Name
Nc recombinant protein
[Similar Products]
Product Synonym Gene Name
Nc[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
135-320aa, Full Length of Mature Protein
Sequence
DTPSPEASEG PCVSKLRNEP LGALTPYVGV VDGPEVKKSK KIHGGDSAIL GTYKMQSRFN RGVLLMVNIM DYPDQNRRRI GAEKDSKSLI HLFQELNFTI FPYGNVNQDQ FFKLLTMVTS SSYVQNTECF VMVLMTHGNS VEGKEKVEFC DGSVVDMQKI KDHFQTAKCP YLVNKPKVLM FPFCRG
3D Structure
ModBase 3D Structure for Q9XYF4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Drosophila melanogaster (Fruit fly)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Nc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Nc. It may not necessarily be applicable to this product.
NCBI Accession #
NP_524017.1
[Other Products]
NCBI GenBank Nucleotide #
NM_079293.4
[Other Products]
UniProt Primary Accession #
Q9XYF4
[Other Products]
UniProt Related Accession #
Q9XYF4[Other Products]
Molecular Weight
51,141 Da
NCBI Official Full Name
death regulator Nedd2-like caspase
NCBI Official Synonym Full Names
Death regulator Nedd2-like caspase
NCBI Official Symbol
Dronc [Similar Products]
NCBI Official Synonym Symbols
anon-EST:GreesD6; anon-EST:GressD6; anon-WO0118547.313; caspase-9; CG8090; CG8091; DmelCG8091; dronc; DRONC; Dronc/Casp9; Nc; NcDronc
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NCBI Protein Information
CG8091 gene product from transcript CG8091-RA
UniProt Protein Name
Caspase Dronc
UniProt Synonym Protein Names
NEDD2-like caspase
UniProt Gene Name
Dronc [Similar Products]
UniProt Comments for Nc
Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.
Research Articles on Nc
1. Activation of epidermal Dronc induces TNF-dependent but effector caspase-independent nociceptive sensitization in the absence of UV. In addition, knockdown of Dronc attenuated nociceptive sensitization induced by full-length TNF/Eiger but not by a constitutively soluble form. UV irradiation induced TNF production in both in vitro and in vivo
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.