Product Name
CDSN, Polyclonal Antibody
Popular Item
Full Product Name
CDSN Polyclonal Antibody
Product Synonym Names
HTSS; HTSS1; HYPT2; PSS; PSS1; S
Product Gene Name
anti-CDSN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
GGSAGSFKPG TGYSQVSYSS GSGSSLQGAS GSSQLGSSSS HSGSSGSHSG SSSSHSSSSS SFQFSSSSFQ VGNGSALPTN DNSYRGILNP SQPGQSSSSS Q
3D Structure
ModBase 3D Structure for Q15517
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
A synthetic peptide of human CDSN
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Secreted
Positive Samples
BXPC-3, A-431, NIH/3T3, Mouse Skin, Mouse skeletal muscle, Rat skin, Rat skeletal muscle
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-CDSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDSN antibody
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
Product Categories/Family for anti-CDSN antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-CDSN antibody
Western Blot (WB)
Application Notes for anti-CDSN antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-CDSN antibody
Western blot analysis of extracts of various cell lines, using CDSN antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
NCBI/Uniprot data below describe general gene information for CDSN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001255.3
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NCBI GenBank Nucleotide #
NM_001264.4
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UniProt Primary Accession #
Q15517
[Other Products]
UniProt Secondary Accession #
O43509; Q5SQ85; Q5STD2; Q7LA70; Q7LA71; Q86Z04; Q8IZU4; Q8IZU5; Q8IZU6; B0S7V2; B0UYZ7[Other Products]
UniProt Related Accession #
Q15517[Other Products]
Molecular Weight
Calculated: 51kDa
Observed: 48kDa
NCBI Official Full Name
corneodesmosin
NCBI Official Synonym Full Names
corneodesmosin
NCBI Official Symbol
CDSN [Similar Products]
NCBI Official Synonym Symbols
S; PSS; HTSS; PSS1; HTSS1; HYPT2
[Similar Products]
NCBI Protein Information
corneodesmosin
UniProt Protein Name
Corneodesmosin
UniProt Synonym Protein Names
S protein
Protein Family
Corneodesmosin
UniProt Gene Name
CDSN [Similar Products]
NCBI Summary for CDSN
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
UniProt Comments for CDSN
Important for the epidermal barrier integrity.
Research Articles on CDSN
1. We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P
Precautions
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Disclaimer
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