Full Product Name
Rat Anti-Mouse ALS
Product Synonym Names
Igfals; ALS; Albs; mKIAA4111
Product Gene Name
anti-ALS antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000083.6 (24877643..24882011). Location: 17 A2-A3; 17 12.53 cM
3D Structure
ModBase 3D Structure for P70389
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of ALS.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ALS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALS antibody
ALS (Acid labile subunit) is an 84-86 kDa glycoprotein member of the leucine rich repeat superfamily of molecules. It is secreted by hepatocytes in response to growth hormone stimulation, and forms a 140-150 kDa ternary complex with IGFBP3 (or IGFBP5) and IGFI. This complex increases the half-life of IGFI and retains it in the circulation for use in multiple tissues. Mature mouse ALS is 580 amino acids (aa) in length (aa 24-603). It contains twentyone 20-23 aa LRRs that participate in proteinprotein interactions. There are two potential isoform variants that show N-terminal extensions. One contains a 66 aa substitution for aa 1 -5, while another possesses an 89 aa substitution again for aa 15. Over aa 28-603, mouse ALS shares 79% and 93% aa identity with human and rat ALS, respectively.
Applications Tested/Suitable for anti-ALS antibody
Western Blot (WB)
Application Notes for anti-ALS antibody
1. Western blotting: Yes (1:500-1000)
NCBI/Uniprot data below describe general gene information for ALS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032366.2
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NCBI GenBank Nucleotide #
NM_008340.3
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UniProt Primary Accession #
P70389
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UniProt Secondary Accession #
Q9DBI7[Other Products]
UniProt Related Accession #
P70389[Other Products]
Molecular Weight
66,960 Da
NCBI Official Full Name
insulin-like growth factor-binding protein complex acid labile subunit
NCBI Official Synonym Full Names
insulin-like growth factor binding protein, acid labile subunit
NCBI Official Symbol
Igfals [Similar Products]
NCBI Official Synonym Symbols
ALS; Albs; mKIAA4111
[Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein complex acid labile subunit
UniProt Protein Name
Insulin-like growth factor-binding protein complex acid labile subunit
UniProt Gene Name
Igfals [Similar Products]
UniProt Synonym Gene Names
Albs; Als; ALS [Similar Products]
UniProt Entry Name
ALS_MOUSE
UniProt Comments for ALS
Function: May have an important role in regulating the access of circulating IGFs to the tissues.
Subunit structure: Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3
By similarity.
Subcellular location: Secreted › extracellular space.
Sequence similarities: Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
Research Articles on ALS
1. A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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