Product Name
Cyclin D1 (CCND1), Antibody
Full Product Name
Cyclin D1 Antibody
Product Gene Name
anti-CCND1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P25322
Other Notes
Small volumes of anti-CCND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot of anti-CCND1 antibody
Western blot analysis on MCF-7 using anti-cyclin D1 polyclonal antibody
NCBI/Uniprot data below describe general gene information for CCND1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031657.1
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NCBI GenBank Nucleotide #
NM_007631.2
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UniProt Primary Accession #
P25322
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UniProt Related Accession #
P25322[Other Products]
Molecular Weight
33,429 Da
NCBI Official Full Name
G1/S-specific cyclin-D1
NCBI Official Synonym Full Names
cyclin D1
NCBI Official Symbol
Ccnd1 [Similar Products]
NCBI Official Synonym Symbols
cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI327039
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NCBI Protein Information
G1/S-specific cyclin-D1
UniProt Protein Name
G1/S-specific cyclin-D1
Protein Family
G1/S-specific cyclin
UniProt Gene Name
Ccnd1 [Similar Products]
UniProt Synonym Gene Names
Cyl-1 [Similar Products]
UniProt Comments for CCND1
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner ().
Research Articles on CCND1
1. beta-catenin and p65 are activated in separate cellular compartments during liver regeneration, with p65 activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 expression, and subsequent proliferation
Precautions
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Disclaimer
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