Full Product Name
Mouse Monoclonal Antibody to DDIT3
Product Synonym Names
CHOP; CEBPZ; CHOP10; CHOP-10; GADD153
Product Gene Name
anti-DDIT3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35639
Other Notes
Small volumes of anti-DDIT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DDIT3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-DDIT3 antibody
Western blot using Recombinant protein
Western blot using Transfection expressed protein
NCBI/Uniprot data below describe general gene information for DDIT3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001277112.1
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NCBI GenBank Nucleotide #
NM_001290183.1
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UniProt Primary Accession #
P35639
[Other Products]
UniProt Secondary Accession #
Q91YW9[Other Products]
UniProt Related Accession #
P35639[Other Products]
NCBI Official Full Name
DNA damage-inducible transcript 3 protein
NCBI Official Synonym Full Names
DNA-damage inducible transcript 3
NCBI Official Symbol
Ddit3 [Similar Products]
NCBI Official Synonym Symbols
chop; CHOP10; CHOP-10; gadd153
[Similar Products]
NCBI Protein Information
DNA damage-inducible transcript 3 protein
UniProt Protein Name
DNA damage-inducible transcript 3 protein
UniProt Synonym Protein Names
C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA-damage-inducible protein GADD153
Protein Family
DNA damage-inducible transcript 3 protein
UniProt Gene Name
Ddit3 [Similar Products]
UniProt Synonym Gene Names
Chop; Chop10; Gadd153; DDIT-3; CHOP; CHOP-10 [Similar Products]
UniProt Comments for DDIT3
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP s in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling.
Research Articles on DDIT3
1. We demonstrated that PPARalpha activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF), particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARalpha as a potential therapeutic strategy to ameliorate ALF.
Precautions
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Disclaimer
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