GUCY2D, Polyclonal Antibody

CORD6; GUC1A4; GUC2D; RETGC; RETGC1; Retinal guanylyl cyclase 1; RETGC-1; Guanylate cyclase 2D, retinal; Rod outer segment membrane guanylate cyclase; ROS-GC

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of GUCY2D protein.

Purified by immunogen affinity chromatography

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-GUCY2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to GUCY2D

Western Blot (WB)

WB: 1/500 - 1/2000

Western blot analysis of GUCY2D expression in mouse brain (A), mouse kidney (B) whole cell lysates.

120,059 Da

guanylate cyclase 2D, retinal

retinal guanylyl cyclase 1

Retinal guanylyl cyclase 1

CORD6; GUC1A4; GUC2D; RETGC; RETGC1; RETGC-1; ROS-GC  [Similar Products]

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

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