Product Synonym Names
DHOF; FODH; MG61; PORC; PPN
Product Gene Name
anti-PORCN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H237
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human PORCN
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PORCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PORCN antibody
This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Applications Tested/Suitable for anti-PORCN antibody
Western Blot (WB)
Application Notes for anti-PORCN antibody
WB: 1:500-1:1000
NCBI/Uniprot data below describe general gene information for PORCN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269096.1
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NCBI GenBank Nucleotide #
NM_001282167.1
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UniProt Primary Accession #
Q9H237
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UniProt Secondary Accession #
Q14829; Q9H234; Q9H235; Q9H236; Q9UJU7; B2RBN8; B7ZAR3[Other Products]
UniProt Related Accession #
Q9H237[Other Products]
NCBI Official Full Name
protein-serine O-palmitoleoyltransferase porcupine isoform F
NCBI Official Synonym Full Names
porcupine O-acyltransferase
NCBI Official Symbol
PORCN [Similar Products]
NCBI Official Synonym Symbols
PPN; DHOF; FODH; MG61; PORC
[Similar Products]
NCBI Protein Information
protein-serine O-palmitoleoyltransferase porcupine
UniProt Protein Name
Protein-serine O-palmitoleoyltransferase porcupine
UniProt Synonym Protein Names
Protein MG61
UniProt Gene Name
PORCN [Similar Products]
NCBI Summary for PORCN
This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
UniProt Comments for PORCN
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.
Research Articles on PORCN
1. Case Report: mosaicism for PORCN mutations in focal dermal hypoplasia (Goltz Syndrome).
Precautions
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Disclaimer
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