Full Product Name
Anti-PAX4 Antibody
Product Synonym Names
Paired box protein Pax-4
Product Gene Name
anti-PAX4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43316
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of PAX4 protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human PAX4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-PAX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAX4 antibody
Rabbit polyclonal antibody to PAX4
Applications Tested/Suitable for anti-PAX4 antibody
Western Blot (WB)
Application Notes for anti-PAX4 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-PAX4 antibody
Western blot analysis of PAX4 expression in Lovo (A) whole cell lysates.
NCBI/Uniprot data below describe general gene information for PAX4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006184.2
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NCBI GenBank Nucleotide #
NM_006193.2
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UniProt Primary Accession #
O43316
[Other Products]
UniProt Secondary Accession #
O95161; Q6B0H0[Other Products]
UniProt Related Accession #
O43316[Other Products]
Molecular Weight
37,061 Da
NCBI Official Full Name
paired box protein Pax-4
NCBI Official Synonym Full Names
paired box 4
NCBI Official Symbol
PAX4 [Similar Products]
NCBI Official Synonym Symbols
KPD; MODY9
[Similar Products]
NCBI Protein Information
paired box protein Pax-4
UniProt Protein Name
Paired box protein Pax-4
Protein Family
Paired box protein
UniProt Gene Name
PAX4 [Similar Products]
NCBI Summary for PAX4
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
UniProt Comments for PAX4
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter . Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
Research Articles on PAX4
1. Study identified the association of a PAX4 Asian-specific missense variant rs2233580 with type 2 diabetes in an exome-chip association analysis, supporting the involvement of PAX4 in the pathogenesis of type 2 diabetes.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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