Full Product Name
Anti-DCXR Antibody
Product Synonym Names
L-xylulose reductase; XR; Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H
Product Gene Name
anti-DCXR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7Z4W1
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of DCXR protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human DCXR
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DCXR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DCXR antibody
Rabbit polyclonal antibody to DCXR
Applications Tested/Suitable for anti-DCXR antibody
Western Blot (WB)
Application Notes for anti-DCXR antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-DCXR antibody
Western blot analysis of DCXR expression in MCF7 (A), mouse liver (B), rat liver (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for DCXR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001182147.1
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NCBI GenBank Nucleotide #
NM_001195218.1
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UniProt Primary Accession #
Q7Z4W1
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UniProt Secondary Accession #
Q9BTZ3; Q9UHY9[Other Products]
UniProt Related Accession #
Q7Z4W1[Other Products]
Molecular Weight
25,913 Da
NCBI Official Full Name
L-xylulose reductase isoform 2
NCBI Official Synonym Full Names
dicarbonyl/L-xylulose reductase
NCBI Official Symbol
DCXR [Similar Products]
NCBI Official Synonym Symbols
XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1
[Similar Products]
NCBI Protein Information
L-xylulose reductase
UniProt Protein Name
L-xylulose reductase
UniProt Synonym Protein Names
Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Short chain dehydrogenase/reductase family 20C member 1; Sperm surface protein P34H
UniProt Gene Name
DCXR [Similar Products]
UniProt Synonym Gene Names
SDR20C1; XR; kiDCR [Similar Products]
UniProt Entry Name
DCXR_HUMAN
NCBI Summary for DCXR
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
UniProt Comments for DCXR
DCXR: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: EC 1.1.1.10; Carbohydrate Metabolism - pentose and glucuronate interconversions; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: brush border; cytoplasmic microtubule; microvillus; nucleus; plasma membrane
Molecular Function: L-xylulose reductase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
Biological Process: D-xylose metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; NADP metabolic process; protein homotetramerization; xylulose metabolic process
Disease: Pentosuria
Research Articles on DCXR
1. EGCG is a potential inhibitor to human DCXR.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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