PORCN, Blocking Peptide

Protein-cysteine N-palmitoyltransferase porcupine; 231-; Protein MG61; PORCN; MG61; PORC; PPN

For Research Use Only. Not for use in diagnostic procedures.

The synthetic peptide sequence is selected from aa 138-151 of HUMAN PORCN

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of PORCN blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members.

42,878 Da

porcupine homolog (Drosophila)

protein-serine O-palmitoleoyltransferase porcupine

Protein-serine O-palmitoleoyltransferase porcupine

PORCN_HUMAN

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]

PORCN: protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. Defects in PORCN are the cause of focal dermal hypoplasia (FODH); also known as Goltz Gorlin syndrome. A rare congenital ectomesodermal disorder characterized by a combination of skin defects, skeletal abnormalities, and ocular anomalies. Affected individuals have patchy dermal hypoplasia, often in a distribution pattern following the Blaschko lines, and areas of subcutaneous fat herniation or deposition of fat into the dermis. In addition, sparse and brittle hair, hypoplastic nails and papillomas have been described. Skeletal abnormalities usually comprise syndactyly, ectrodactyly, and brachydactyly, and in some cases osteopathia striata has been seen. Patients frequently have ocular anomalies, including microphthalmia/ anophthalmia, coloboma, pigmentary and vascularization defects of the retina. Dental abnormalities are often present. Belongs to the membrane-bound acyltransferase family. Porcupine subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.-; Membrane protein, multi-pass; Transferase; Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Biological Process: protein amino acid lipidation; protein palmitoleylation; Wnt receptor signaling pathway

Disease: Focal Dermal Hypoplasia

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