Product Name
CORO1A, cDNA Clone
Full Product Name
CORO1A cDNA Clone
Product Gene Name
CORO1A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagccggc aggtggtccg ctccagcaag ttccgccacg tgtttggaca gccggccaag gccgaccagt gctatgaaga tgtgcgcgtc tcacagacca cctgggacag tggcttctgt gctgtcaacc ctaagtttgt ggccctgatc tgtgaggcca gcgggggagg ggccttcctg gtgctgcccc tgggcaagac tggacgtgtg gacaagaatg cgcccacggt ctgtggccac acagcccctg tgctagacat cgcctggtgc ccgcacaatg acaacgtcat tgccagtggc tccgaggact gcacagtcat ggtgtgggag atcccggatg ggggcctgat gctgcccctg cgggagcccg tcgtcaccct ggagggccac accaagcgtg tgggcattgt ggcctggcac accacagccc agaacgtgct gctcagtgca ggttgtgaca acgtgatcat ggtgtgggac gtgggcactg gggcggccat gctgacactg ggcccagagg tgcacccaga cacgatctac agtgtggact ggagccgaga tggaggcctc atttgtacct cctgccgtga caagcgcgtg cgcatcatcg agccccgcaa aggcactgtc gtagctgaga aggaccgtcc ccacgagggg acccggcccg tgcgtgcagt gttcgtgtcg gaggggaaga tcctgaccac gggcttcagc cgcatgagtg agcggcaggt ggcgctgtgg gacacaaagc acctggagga gccgctgtcc ctgcaggagc tggacaccag cagcggtgtc ctgctgccct tctttgaccc tgacaccaac atcgtctacc tctgtggcaa gggtgacagc tcaatccggt actttgagat cacttccgag gcccctttcc tgcactatct ctccatgttc agttccaagg agtcccagcg gggcatgggc tacatgccca aacgtggcct ggaggtgaac aagtgtgaga tcgccaggtt ctacaagctg cacgagcgga ggtgtgagcc cattgccatg acagtgcctc gaaagtcgga cctgttccag gaggacctgt acccacccac cgcagggccc gaccctgccc tcacggctga ggagtggctg gggggtcggg atgctgggcc cctcctcatc tccctcaagg atggctacgt acccccaaag agccgggagc tgagggtcaa ccggggcctg gacaccgggc gcaggagggc agcaccagag gccagtggca ctcccagctc ggatgccgtg tctcggctgg aggaggagat gcggaagctc caggccacgg tgcaggagct ccagaagcgc ttggacaggc tggaggagac agtccaggcc aagtag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CORO1A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CORO1A. It may not necessarily be applicable to this product.
NCBI Accession #
BC126385
[Other Products]
UniProt Secondary Accession #
Q2YD73; B2RBL1[Other Products]
UniProt Related Accession #
P31146[Other Products]
Molecular Weight
51,026 Da
NCBI Official Full Name
Homo sapiens coronin, actin binding protein, 1A, mRNA
NCBI Official Synonym Full Names
coronin 1A
NCBI Official Symbol
CORO1A [Similar Products]
NCBI Official Synonym Symbols
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
[Similar Products]
NCBI Protein Information
coronin-1A
UniProt Protein Name
Coronin-1A
UniProt Synonym Protein Names
Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
UniProt Gene Name
CORO1A [Similar Products]
UniProt Synonym Gene Names
CORO1; Clipin-A; TACO [Similar Products]
UniProt Entry Name
COR1A_HUMAN
NCBI Summary for CORO1A
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
UniProt Comments for CORO1A
coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: actin filament; cortical actin cytoskeleton; cytoplasm; immunological synapse; lamellipodium; membrane; nucleus; phagocytic cup; phagocytic vesicle; plasma membrane; protein complex
Molecular Function: actin binding; actin filament binding; actin monomer binding; cytoskeletal protein binding; myosin heavy chain binding; phosphoinositide 3-kinase binding; protein binding; protein C-terminus binding; protein homodimerization activity
Biological Process: actin cytoskeleton organization and biogenesis; cell-substrate adhesion; formation of immunological synapse; natural killer cell degranulation; negative regulation of actin nucleation; phagocytosis; phagolysosome formation; positive chemotaxis; regulation of actin cytoskeleton organization and biogenesis
Disease: Immunodeficiency 8
Research Articles on CORO1A
1. Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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