Full Product Name
Rabbit SCN4B Antibody
Product Gene Name
anti-SCN4B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (118004092..118023630, complement). Location: 11q23.3
3D Structure
ModBase 3D Structure for Q8IWT1
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-SCN4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SCN4B antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SCN4B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001135820.1
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NCBI GenBank Nucleotide #
NM_001142348.1
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UniProt Primary Accession #
Q8IWT1
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UniProt Secondary Accession #
Q6PIG5[Other Products]
UniProt Related Accession #
Q8IWT1[Other Products]
Molecular Weight
24,969 Da
NCBI Official Full Name
sodium channel subunit beta-4 isoform 2
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type IV, beta subunit
NCBI Official Symbol
SCN4B [Similar Products]
NCBI Official Synonym Symbols
LQT10; Navbeta4
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NCBI Protein Information
sodium channel subunit beta-4
UniProt Protein Name
Sodium channel subunit beta-4
Protein Family
Sodium channel
UniProt Gene Name
SCN4B [Similar Products]
UniProt Entry Name
SCN4B_HUMAN
NCBI Summary for SCN4B
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for SCN4B
SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: voltage-gated sodium channel complex; intrinsic to plasma membrane
Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: sodium ion transport; cardiac muscle contraction
Disease: Long Qt Syndrome 10
Research Articles on SCN4B
1. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells.
Precautions
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Disclaimer
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