NFAM1, Polyclonal Antibody

Anti -NFAM1 (NFAT Activation Molecule 1, Calcineurin/NFAT-activating ITAM-containing Protein, NFAT-activating Protein with ITAM Motif 1, CNAIP, bK126B4.4, FLJ40652)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 22; NC_000022.10 (42776413..42833086, complement). Location: 22q13.2

Polyclonal

IgG

Mouse

Recognizes human NFAM1.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-NFAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. It is also known CNAIP.

Antibodies; Abs to Signal Transduction

Western Blot (WB), Immunofluorescence (IF)

Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

29,686 Da[Similar Products]

NFAT activating protein with ITAM motif 1

NFAT activation molecule 1; NFAT-activating protein with ITAM motif 1; calcinerin/NFAT-activating ITAM-containing protein; calcineurin/NFAT-activating ITAM-containing protein

NFAT activation molecule 1

CNAIP  [Similar Products]

NFAM1_HUMAN

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. Ref.1 Ref.2

Subunit structure: No direct interaction with the B-cell antigen receptor (BCR). Interacts with SYK; probably involved in BCR signaling. Interacts with ZAP70

By similarity. Ref.2

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Note: Partially recruited to lipid rafts upon BCR stimulation

By similarity. Ref.1 Ref.2

Tissue specificity: Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. Ref.1 Ref.2

Domain: The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.

Post-translational modification: N-glycosylated. Ref.2

Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 1 ITAM domain.

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