Product Name
CORO1A, Polyclonal Antibody
Full Product Name
CORO1A Antibody, HRP conjugated
Product Synonym Names
Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO; CORO1A; CORO1
Product Gene Name
anti-CORO1A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31146
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Coronin-1A protein (363-432AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133476
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CORO1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CORO1A antibody
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Applications Tested/Suitable for anti-CORO1A antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CORO1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001180262.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001193333.2
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UniProt Primary Accession #
P31146
[Other Products]
UniProt Secondary Accession #
Q2YD73; B2RBL1[Other Products]
UniProt Related Accession #
P31146[Other Products]
Molecular Weight
51,026 Da
NCBI Official Full Name
coronin-1A
NCBI Official Synonym Full Names
coronin 1A
NCBI Official Symbol
CORO1A [Similar Products]
NCBI Official Synonym Symbols
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
[Similar Products]
NCBI Protein Information
coronin-1A
UniProt Protein Name
Coronin-1A
UniProt Synonym Protein Names
Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
UniProt Gene Name
CORO1A [Similar Products]
UniProt Synonym Gene Names
CORO1; Clipin-A; TACO [Similar Products]
UniProt Entry Name
COR1A_HUMAN
NCBI Summary for CORO1A
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
UniProt Comments for CORO1A
coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: actin filament; cortical actin cytoskeleton; cytoplasm; immunological synapse; lamellipodium; membrane; nucleus; phagocytic cup; phagocytic vesicle; plasma membrane; protein complex
Molecular Function: actin binding; actin filament binding; actin monomer binding; cytoskeletal protein binding; myosin heavy chain binding; phosphoinositide 3-kinase binding; protein binding; protein C-terminus binding; protein homodimerization activity
Biological Process: actin cytoskeleton organization and biogenesis; cell-substrate adhesion; formation of immunological synapse; natural killer cell degranulation; negative regulation of actin nucleation; phagocytosis; phagolysosome formation; positive chemotaxis; regulation of actin cytoskeleton organization and biogenesis
Disease: Immunodeficiency 8
Research Articles on CORO1A
1. Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens.
Precautions
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Disclaimer
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