Coro1A, Polyclonal Antibody

Coro1A Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Purified whole serum by affinity chromatography.

Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.

Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch

Small volumes of anti-CORO1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit anti CORO1A antibody recognizes coronin 1A (encoded by the CORO1A gene), also known as clipin-A, coronin-like protein p57 or tryptophan-aspartate-containing coat protein (TACO). Coronin 1A is a member of the WD repeat coronin protein family. Coronin 1A is expressed by leukocytes and is implicated in cytoskeleton remodeling.

Western Blot (WB)

WB: 1:500-1:2000

Western blot analysis of Jurkat cell lysate using Rabbit anti CORO1A antibody

51,026 Da

coronin 1A

coronin-1A

Coronin-1A

CORO1; Clipin-A; TACO  [Similar Products]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

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