Product Name
LMX1B, cDNA Clone
Full Product Name
LMX1B cDNA Clone
Product Gene Name
LMX1B cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgttggacg gcatcaagat ggaggagcac gccctgcgcc ccgggcccgc cactctgggg gtgctgctgg gctccgactg cccgcatccc gccgtctgcg agggctgcca gcggcccatc tccgaccgct tcctgatgcg agtcaacgag tcgtcctggc acgaggagtg tttgcagtgc gcggcgtgtc agcaagccct caccaccagc tgctacttcc gggatcggaa actgtactgc aaacaagact accaacagct cttcgcggcc aagtgcagcg gctgcatgga gaagatcgcc cccaccgagt tcgtgatgcg ggcgctggag tgcgtgtacc acctgggctg cttctgctgc tgcgtgtgtg agcggcagct acgcaagggc gacgaattcg tgctcaagga gggccagctg ctgtgcaagg gtgactacga gaaggagaag gacctgctca gctccgtgag ccccgacgag tccgactccg tgaagagcga ggatgaagat ggggacatga agccggccaa ggggcagggc agtcagagca agggcagcgg ggatgacggg aaggacccgc ggaggcccaa gcgaccccgg accatcctca ccacgcagca gcgaagagcc ttcaaggcct ccttcgaggt ctcgtccaag ccttgccgaa aggtccgaga gacactggca gctgagacgg gcctcagtgt gcgcgtggtc caggtctggt ttcagaacca aagagcaaag atgaagaagc tggcgcggcg gcaccagcag cagcaggagc agcagaactc ccagcggctg ggccaggagg tcctgtccag ccgcatggag ggcatgatgg cttcctacac gccgctggcc ccaccacagc agcagatcgt ggccatggaa cagagcccct acggcagcag cgaccccttc cagcagggcc tcacgccgcc ccaaatgcca gggaacgact ccatcttcca tgacatcgac agcgatacct ccttaaccag cctcagcgac tgcttcctcg gctcctcaga cgtgggctcc ctgcaggccc gcgtggggaa ccccatcgac cggctctact ccatgcagag ttcctacttc gcctcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of LMX1B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for LMX1B. It may not necessarily be applicable to this product.
NCBI Accession #
BC069601
[Other Products]
UniProt Secondary Accession #
O75463; Q5JU95; Q6ISC9; F8W7W6[Other Products]
UniProt Related Accession #
O60663[Other Products]
Molecular Weight
45,080 Da
NCBI Official Full Name
Homo sapiens LIM homeobox transcription factor 1, beta, mRNA
NCBI Official Synonym Full Names
LIM homeobox transcription factor 1 beta
NCBI Official Symbol
LMX1B [Similar Products]
NCBI Official Synonym Symbols
NPS1; LMX1.2
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NCBI Protein Information
LIM homeobox transcription factor 1-beta
UniProt Protein Name
LIM homeobox transcription factor 1-beta
UniProt Synonym Protein Names
LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
Protein Family
LIM/homeobox protein
UniProt Gene Name
LMX1B [Similar Products]
UniProt Synonym Gene Names
LMX-1.2 [Similar Products]
UniProt Entry Name
LMX1B_HUMAN
NCBI Summary for LMX1B
This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for LMX1B
LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: dorsal/ventral pattern formation; neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
Disease: Nail-patella Syndrome
Research Articles on LMX1B
1. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review]
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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