FARP2, Polyclonal Antibody

FERM; RhoGEF and pleckstrin domain-containing protein 2; FARP2; KIAA0793; PLEKHC3; FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-FARP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

ELISA (EIA)

72,263 Da

FERM, ARH/RhoGEF and pleckstrin domain protein 2

FERM, RhoGEF and pleckstrin domain-containing protein 2

FERM, RhoGEF and pleckstrin domain-containing protein 2

KIAA0793; PLEKHC3; FIR; PH domain-containing family C member 3  [Similar Products]

FARP2_HUMAN

FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, Rac/Rho; Cell development/differentiation

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; extrinsic to membrane

Molecular Function: cytoskeletal protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton reorganization; axon guidance; cell adhesion; neuron remodeling; osteoclast differentiation; positive regulation of GTPase activity; Rac protein signal transduction; regulation of integrin activation; regulation of Rho protein signal transduction

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