Full Product Name
FIR Antibody
Product Synonym Names
FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG
Product Gene Name
anti-FIR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O94887
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total FIR protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from Internal of human FIR.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-FIR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FIR antibody
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.Nagase T., DNA Res. 5:31-39(1998).The MGC Project Team, Genome Res. 14:2121-2127(2004).Jandrig B., Oncogene 23:9295-9302(2004).
Product Categories/Family for anti-FIR antibody
Total protein Ab
Applications Tested/Suitable for anti-FIR antibody
Western Blot (WB)
Application Notes for anti-FIR antibody
Western blotting: 1:500~1:3000
Western Blot (WB) of anti-FIR antibody
Western blot analysis of extracts from HuvEc cells, using FIR antibody.
NCBI/Uniprot data below describe general gene information for FIR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269912.1
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NCBI GenBank Nucleotide #
NM_001282983.1
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UniProt Primary Accession #
O94887
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UniProt Secondary Accession #
Q53QM5; Q8WU27; Q9UFE7; B7Z6J8; F5GZ84[Other Products]
UniProt Related Accession #
O94887[Other Products]
Molecular Weight
72,263 Da
NCBI Official Full Name
FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform b
NCBI Official Synonym Full Names
FERM, RhoGEF and pleckstrin domain protein 2
NCBI Official Symbol
FARP2 [Similar Products]
NCBI Official Synonym Symbols
FIR; FRG; PLEKHC3
[Similar Products]
NCBI Protein Information
FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Protein Name
FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Synonym Protein Names
FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3
UniProt Gene Name
FARP2 [Similar Products]
UniProt Synonym Gene Names
KIAA0793; PLEKHC3; FIR; PH domain-containing family C member 3 [Similar Products]
UniProt Entry Name
FARP2_HUMAN
UniProt Comments for FIR
FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; Motility/polarity/chemotaxis; Cell development/differentiation; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoskeleton; extrinsic to membrane; cytoplasm; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; cytoskeletal protein binding
Biological Process: axon guidance; regulation of integrin activation; actin cytoskeleton reorganization; Rac protein signal transduction; osteoclast differentiation; cell adhesion; neuron remodeling
Research Articles on FIR
1. Observational study of gene-disease association. (HuGE Navigator)
Precautions
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Disclaimer
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