Aldehyde dehydrogenase, mitochondrial, ELISA Kit

Aldehyde dehydrogenase, mitochondrial; AHD-M1; ALDH class 2; ALDH-E2; ALDHI; Aldh2; Ahd-1; Ahd1; 1.2.1.3

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of Aldh2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2882400 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Aldehyde dehydrogenase, mitochondrial (Aldh2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Aldh2. The ELISA analytical biochemical technique of the MBS2882400 kit is based on Aldh2 antibody-Aldh2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Aldh2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Aldh2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

56,538 Da

aldehyde dehydrogenase 2, mitochondrial

aldehyde dehydrogenase, mitochondrial

Aldehyde dehydrogenase, mitochondrial

Ahd-1; Ahd1  [Similar Products]

ALDH2_MOUSE

ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Protein type: Oxidoreductase; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - tryptophan; EC 1.2.1.3; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - limonene and pinene degradation; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - ascorbate and aldarate; Amino Acid Metabolism - lysine degradation; Mitochondrial; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - butanoate; Lipid Metabolism - glycerolipid

Cellular Component: mitochondrion

Molecular Function: aldehyde dehydrogenase (NAD) activity; identical protein binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; protein binding

Biological Process: metabolic process; negative regulation of apoptosis

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