Filamin A Alpha, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against FLNa. It has beenselected for its ability to recognize FLNa in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-FLNa antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Recombinant FLNa, Human.

DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue

DAB staining on IHC-P; Samples: Human Liver Tissue.

DAB staining on IHC-P; Samples: Human Prostate Gland Tissue.

DAB staining on IHC-P; Samples: Human Stomach Tissue.

280,018 Da

filamin A

filamin-A

Filamin-A

FLN; FLN1; FLN-A; ABP-280  [Similar Products]

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

FLNA: a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: actin cytoskeleton; cell soma; cortical cytoskeleton; cytoplasm; cytosol; dendritic shaft; extracellular exosome; extracellular matrix; extracellular region; filamentous actin; focal adhesion; intercellular junction; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; Z disc

Molecular Function: actin filament binding; cadherin binding; G-protein coupled receptor binding; GTPase binding; ion channel binding; kinase binding; mu-type opioid receptor binding; potassium channel regulator activity; protein binding; protein homodimerization activity; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; RNA binding; signal transducer activity; SMAD binding; small GTPase binding; transcription factor binding

Biological Process: actin crosslink formation; actin cytoskeleton reorganization; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cerebral cortex development; cytoplasmic sequestering of protein; establishment of protein localization; formation of radial glial scaffolds; mitotic spindle assembly; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of protein catabolic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase I promoter; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of integrin-mediated signaling pathway; positive regulation of neural precursor cell proliferation; positive regulation of neuron migration; positive regulation of potassium ion transmembrane transport; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription factor import into nucleus; protein localization to cell surface; protein localization to plasma membrane; protein stabilization; receptor clustering; regulation of cell migration; regulation of membrane repolarization during atrial cardiac muscle cell action potential; regulation of membrane repolarization during cardiac muscle cell action potential; semaphorin-plexin signaling pathway; wound healing, spreading of cells

Disease: Cardiac Valvular Dysplasia, X-linked; Fg Syndrome 2; Frontometaphyseal Dysplasia; Heterotopia, Periventricular, Ehlers-danlos Variant; Heterotopia, Periventricular, X-linked Dominant; Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-linked; Melnick-needles Syndrome; Otopalatodigital Syndrome, Type I; Otopalatodigital Syndrome, Type Ii; Terminal Osseous Dysplasia

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