Full Product Name
ACADM Antibody
Product Synonym Names
MCAD; ACAD1; MCADH
Product Gene Name
anti-ACADM antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11310
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total ACADM protein.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human ACADM.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ACADM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACADM antibody
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-ACADM antibody
Total protein Ab
Applications Tested/Suitable for anti-ACADM antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACADM antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Western Blot (WB) of anti-ACADM antibody
Western blot analysis of extracts of HepG2 cell line, using ACADM antibody.
NCBI/Uniprot data below describe general gene information for ACADM. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000007.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000016.5
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UniProt Primary Accession #
P11310
[Other Products]
UniProt Secondary Accession #
Q5T4U4; Q9NYF1[Other Products]
UniProt Related Accession #
P11310[Other Products]
Molecular Weight
47,020 Da
NCBI Official Full Name
medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
NCBI Official Symbol
ACADM [Similar Products]
NCBI Official Synonym Symbols
MCAD; ACAD1; MCADH
[Similar Products]
NCBI Protein Information
medium-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Protein Family
Medium-chain specific acyl-CoA dehydrogenase
UniProt Gene Name
ACADM [Similar Products]
UniProt Synonym Gene Names
MCAD [Similar Products]
UniProt Entry Name
ACADM_HUMAN
NCBI Summary for ACADM
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACADM
ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Lipid Metabolism - fatty acid; Oxidoreductase; EC 1.3.8.7; Carbohydrate Metabolism - propanoate
Chromosomal Location of Human Ortholog: 1p31
Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus
Molecular Function: acyl-CoA dehydrogenase activity; identical protein binding; FAD binding
Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process
Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of
Research Articles on ACADM
1. mutations in the ACADM gene lower the temperature threshold at which medium-chain acyl-CoA dehydrogenase deficiency loss-of-function occurs.
Precautions
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Disclaimer
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