Full Product Name
ACSL6 Antibody
Product Synonym Names
ACS2; FACL6; FLJ16173; KIAA0837; LACS2; LACS5
Product Gene Name
anti-ACSL6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of ACSL6
Calculated Molecular Weight: 78kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48004 / sc-48003 / sc-48005 / sc-134498
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ACSL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACSL6 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ACSL6. It may not necessarily be applicable to this product.
NCBI Accession #
AAH26161.1
[Other Products]
UniProt Secondary Accession #
O94924; O95829; Q108M9; Q108N0; Q4G191; Q86TN7; J3KPG3[Other Products]
UniProt Related Accession #
Q9UKU0[Other Products]
Molecular Weight
79,040 Da
NCBI Official Full Name
ACSL6 protein
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 6
NCBI Official Symbol
ACSL6 [Similar Products]
NCBI Official Synonym Symbols
ACS2; FACL6; LACS2; LACS5; LACS 6
[Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 6; fatty-acid-Coenzyme A ligase, long-chain 6; long fatty acyl-CoA synthetase 2
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 6
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 6; LACS 6
Protein Family
Long-chain-fatty-acid--CoA ligase
UniProt Gene Name
ACSL6 [Similar Products]
UniProt Synonym Gene Names
ACS2; FACL6; KIAA0837; LACS5; LACS 6 [Similar Products]
UniProt Entry Name
ACSL6_HUMAN
NCBI Summary for ACSL6
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
UniProt Comments for ACSL6
ACSL6: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. Belongs to the ATP-dependent AMP-binding enzyme family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid; EC 6.2.1.3; Ligase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; integral to membrane; plasma membrane; nucleus
Molecular Function: protein homodimerization activity; enzyme binding; ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: response to gravity; acyl-CoA metabolic process; cellular response to insulin stimulus; response to steroid hormone stimulus; neuroblast proliferation; response to hypoxia; neuron development; triacylglycerol biosynthetic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; response to nutrient; fatty acid transport; phospholipid biosynthetic process
Research Articles on ACSL6
1. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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