Full Product Name
Anti-AANAT Antibody
Product Synonym Names
SNAT; Serotonin N-acetyltransferase; Serotonin acetylase; Aralkylamine N-acetyltransferase; AA-NAT
Product Gene Name
anti-AANAT antibody
[Similar Products]
Antibody/Peptide Pairs
AANAT peptide (MBS8243848) is used for blocking the activity of AANAT antibody (MBS8243153)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16613
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of AANAT protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AANAT. The exact sequence is proprietary.
Preparation and Storage
Shipped and store at 4 degree C for one year. Do not freeze.
Other Notes
Small volumes of anti-AANAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AANAT antibody
Rabbit polyclonal antibody to AANAT
Applications Tested/Suitable for anti-AANAT antibody
Western Blot (WB)
Application Notes for anti-AANAT antibody
Western Blot: (1/500 - 1/1000)
Western Blot (WB) of anti-AANAT antibody
Western blot analysis of AANAT expression in A549 (A), PC12 (B) whole cell lysates.
NCBI/Uniprot data below describe general gene information for AANAT. It may not necessarily be applicable to this product.
NCBI Accession #
Q16613.1
[Other Products]
UniProt Primary Accession #
Q16613
[Other Products]
UniProt Secondary Accession #
Q562F4; A0AVF2; J3KMZ5[Other Products]
UniProt Related Accession #
Q16613[Other Products]
Molecular Weight
28,432 Da
NCBI Official Full Name
Serotonin N-acetyltransferase
NCBI Official Synonym Full Names
aralkylamine N-acetyltransferase
NCBI Official Symbol
AANAT [Similar Products]
NCBI Official Synonym Symbols
DSPS; SNAT
[Similar Products]
NCBI Protein Information
serotonin N-acetyltransferase
UniProt Protein Name
Serotonin N-acetyltransferase
UniProt Synonym Protein Names
Aralkylamine N-acetyltransferase; AA-NAT
Protein Family
Serotonin N-acetyltransferase
UniProt Gene Name
AANAT [Similar Products]
UniProt Synonym Gene Names
SNAT; Serotonin acetylase; AA-NAT [Similar Products]
UniProt Entry Name
SNAT_HUMAN
NCBI Summary for AANAT
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for AANAT
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Research Articles on AANAT
1. melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth.">There is dysregulation of the AANAT/ASMT/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth.
Precautions
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Disclaimer
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