AANAT, Polyclonal Antibody

DSPS; SNAT

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

2.4mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-AANAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:50-1:200

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using AANAT Polyclonal Antibody at dilution 1:40

Immunohistochemistry of paraffin-embedded Human brain tissue using AANAT Polyclonal Antibody at dilution 1:40

28,432 Da

aralkylamine N-acetyltransferase

serotonin N-acetyltransferase; arylalkylamine N-acetyltransferase; serotonin acetylase

Serotonin N-acetyltransferase

SNAT; Serotonin acetylase; AA-NAT  [Similar Products]

SNAT_HUMAN

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.

Protein type: Amino Acid Metabolism - tryptophan; EC 2.3.1.87; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: perinuclear region of cytoplasm; cytosol

Molecular Function: arylamine N-acetyltransferase activity; aralkylamine N-acetyltransferase activity

Biological Process: N-terminal protein amino acid acetylation; circadian rhythm; response to light stimulus; melatonin biosynthetic process; response to copper ion; indolalkylamine biosynthetic process; response to zinc ion; response to cytokine stimulus; response to calcium ion; response to corticosterone stimulus; response to insulin stimulus

Disease: Delayed Sleep Phase Syndrome, Susceptibility To

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