Gamma-Aminobutyric Acid A Receptor Alpha 2, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of gammaABRalpha2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS054024 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gamma-Aminobutyric Acid A Receptor Alpha 2 (gammaABRalpha2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing gammaABRalpha2. The ELISA analytical biochemical technique of the MBS054024 kit is based on gammaABRalpha2 antibody-gammaABRalpha2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect gammaABRalpha2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, gammaABRalpha2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

61,623 Da

gamma-aminobutyric acid (GABA) A receptor, alpha 4

gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor, alpha 4; gamma-aminobutyric acid A receptor alpha 4

Gamma-aminobutyric acid receptor subunit alpha-4

GBRA4_HUMAN

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

GABRA4: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.

Protein type: Channel, chloride; Channel, ligand-gated; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; central nervous system development; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway

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