Full Product Name
CHIT1 Polyclonal Antibody
Product Synonym Names
CHI3; CHIT; CHITD
Product Gene Name
anti-CHIT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human CHIT1
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CHIT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHIT1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHIT1 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Western Blot (WB) of anti-CHIT1 antibody
Western blot analysis of extracts of various cells, using CHIT1 antibody.
Immunohistochemistry (IHC) of anti-CHIT1 antibody
Immunohistochemistry of paraffin-embedded human normal stomach using CHIT1 antibody at dilution of1:200 (400x lens).
NCBI/Uniprot data below describe general gene information for CHIT1. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_001270509.1
[Other Products]
UniProt Secondary Accession #
Q0VGG5; Q0VGG6; Q3ZAR1; Q6ISC2; Q9H3V8; Q9UDJ8; B3KNW6; J3KN09[Other Products]
UniProt Related Accession #
Q13231[Other Products]
NCBI Official Full Name
chitotriosidase-1 isoform 3
NCBI Official Synonym Full Names
chitinase 1
NCBI Official Symbol
CHIT1 [Similar Products]
NCBI Official Synonym Symbols
CHI3; CHIT; CHITD
[Similar Products]
NCBI Protein Information
chitotriosidase-1
UniProt Protein Name
Chitotriosidase-1
UniProt Synonym Protein Names
Chitinase-1
Protein Family
Chitotriosidase
UniProt Gene Name
CHIT1 [Similar Products]
UniProt Entry Name
CHIT1_HUMAN
NCBI Summary for CHIT1
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CHIT1
CHIT1: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 3.2.1.14; Hydrolase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: extracellular region; extracellular space
Molecular Function: chitin binding; chitinase activity; endochitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: carbohydrate metabolic process; chitin catabolic process; response to bacterium
Disease: Chitotriosidase Deficiency
Research Articles on CHIT1
1. BALF chitotriosidase activity is increased in patients with sarcoidosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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