Full Product Name
Anti-CHIT1 Antibody
Product Gene Name
anti-CHIT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13231
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human CHIT1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CHIT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHIT1 antibody
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture.
Applications Tested/Suitable for anti-CHIT1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHIT1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for CHIT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003456.1
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NCBI GenBank Nucleotide #
NM_003465.2
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UniProt Primary Accession #
Q13231
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UniProt Secondary Accession #
Q0VGG5; Q0VGG6; Q3ZAR1; Q6ISC2; Q9H3V8; Q9UDJ8; B3KNW6; J3KN09[Other Products]
UniProt Related Accession #
Q13231[Other Products]
Molecular Weight
49,613 Da
NCBI Official Full Name
chitotriosidase-1 isoform 1
NCBI Official Synonym Full Names
chitinase 1
NCBI Official Symbol
CHIT1 [Similar Products]
NCBI Official Synonym Symbols
CHI3; CHIT; CHITD
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NCBI Protein Information
chitotriosidase-1
UniProt Protein Name
Chitotriosidase-1
UniProt Synonym Protein Names
Chitinase-1
Protein Family
Chitotriosidase
UniProt Gene Name
CHIT1 [Similar Products]
NCBI Summary for CHIT1
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CHIT1
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Research Articles on CHIT1
1. /=70.">All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or Niemann-Pick disease type C suspicion index scores >/=70.
Precautions
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Disclaimer
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