Full Product Name
FIGLA, ID (FIGLA, BHLHC8, Factor in the germline alpha, Class C basic helix-loop-helix protein 8, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa)
Product Synonym Names
Anti -FIGLA, ID (FIGLA, BHLHC8, Factor in the germline alpha, Class C basic helix-loop-helix protein 8, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa)
Product Gene Name
anti-FIGLA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (71004442..71017775, complement). Location: 2p13.3
3D Structure
ModBase 3D Structure for Q6QHK4
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
FIGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from the Central region of human FIGLA.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-FIGLA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FIGLA antibody
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
Product Categories/Family for anti-FIGLA antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-FIGLA antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-FIGLA antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for FIGLA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001004311.2
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NCBI GenBank Nucleotide #
NM_001004311.3
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UniProt Primary Accession #
Q6QHK4
[Other Products]
UniProt Related Accession #
Q6QHK4[Other Products]
Molecular Weight
24,123 Da[Similar Products]
NCBI Official Full Name
factor in the germline alpha
NCBI Official Synonym Full Names
folliculogenesis specific basic helix-loop-helix
NCBI Official Symbol
FIGLA [Similar Products]
NCBI Official Synonym Symbols
POF6; BHLHC8; FIGALPHA
[Similar Products]
NCBI Protein Information
factor in the germline alpha; transcription factor FIGa; class C basic helix-loop-helix protein 8; folliculogenesis-specific basic helix-loop-helix protein
UniProt Protein Name
Factor in the germline alpha
UniProt Synonym Protein Names
Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa
Protein Family
Factor in the germline
UniProt Gene Name
FIGLA [Similar Products]
UniProt Synonym Gene Names
BHLHC8; FIGalpha; bHLHc8 [Similar Products]
UniProt Entry Name
FIGLA_HUMAN
NCBI Summary for FIGLA
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
UniProt Comments for FIGLA
FIGLA: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in ***** females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: transcription factor complex; nucleus
Molecular Function: protein dimerization activity; sequence-specific DNA binding; transcription factor binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; oocyte development
Disease: Premature Ovarian Failure 6
Research Articles on FIGLA
1. may have a role in the development of primordial follicle before zona pellucida formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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