Product Name
FIGLA, Blocking Peptide
Full Product Name
FIGLA Antibody (Center) Blocking Peptide
Product Synonym Names
Factor in the germline alpha; FIGalpha; Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa; FIGLA; BHLHC8
Product Gene Name
FIGLA blocking peptide
[Similar Products]
Product Synonym Gene Name
BHLHC8[Similar Products]
Antibody/Peptide Pairs
FIGLA peptide (MBS9223048) is used for blocking the activity of FIGLA antibody (MBS9212631)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6QHK4
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Nucleus.
Tissue Location
Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of FIGLA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FIGLA blocking peptide
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in ***** females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
NCBI/Uniprot data below describe general gene information for FIGLA. It may not necessarily be applicable to this product.
NCBI Accession #
Q6QHK4.2
[Other Products]
UniProt Primary Accession #
Q6QHK4
[Other Products]
UniProt Related Accession #
Q6QHK4[Other Products]
Molecular Weight
24,123 Da
NCBI Official Full Name
Factor in the germline alpha
NCBI Official Synonym Full Names
folliculogenesis specific bHLH transcription factor
NCBI Official Symbol
FIGLA [Similar Products]
NCBI Official Synonym Symbols
POF6; BHLHC8; FIGALPHA
[Similar Products]
NCBI Protein Information
factor in the germline alpha
UniProt Protein Name
Factor in the germline alpha
UniProt Synonym Protein Names
Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa
Protein Family
Factor in the germline
UniProt Gene Name
FIGLA [Similar Products]
UniProt Synonym Gene Names
BHLHC8; FIGalpha; bHLHc8 [Similar Products]
UniProt Entry Name
FIGLA_HUMAN
NCBI Summary for FIGLA
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
UniProt Comments for FIGLA
FIGLA: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in ***** females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: transcription factor complex
Molecular Function: sequence-specific DNA binding; transcription factor binding
Disease: Premature Ovarian Failure 6
Research Articles on FIGLA
1. C and c.557C->T alleles lead to an increased risk of POF in Indian women">study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF in Indian women
Precautions
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Disclaimer
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